Like everyone, LGBTQIA2+ people want health care and affirming work environments where they are welcome and respected. LGBTQIA2+ people generally experience higher rates of HIV infection, depression, suicidal behavior, homelessness, smoking, and substance use while facing barriers to access inclusive and affirming care. This course is a new 3-day training, which is intended for any organization in contact with LGBTQIA2+ individuals (including mental health and substance use disorder clinicians, HIV providers, state, local and county government employees, primary care providers, public health practitioners, prevention specialists, community based organizations, school teachers, and counselors).